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Administrative Supplements for
Research on HIV/AIDS-Related Cancers Among Racial/Ethnic Minority and Underserved Persons in the United States

Guidelines for Application, Review and Award

Supplement Title:
Administrative Supplements for Research on HIV/AIDS-Related Cancers Among Racial/Ethnic Minority and Underserved Persons in the U.S.

Application Deadline: July 20, 2009


The Center to Reduce Cancer Health Disparities (CRCHD) of the National Cancer Institute (NCI) announces for the fiscal year of 2009 the opportunity for grantees to seek administrative supplemental funding to extend their program of research to include cancer among HIV-infected persons from racial/ethnic minorities or the underserved. This 1-year administrative supplement is limited to NCI CRCHD’s Community Networks Program (CNP), Minority Institutions/Cancer Center Partnership (MI/CCP), and Patient Navigation Research Program (PNRP). These programs may apply for an administrative supplement provided the following conditions are met:

  1. The original cancer research grant or cooperative agreement involves basic, clinical, behavioral or population-science research that is designed to reduce/eliminate cancer health disparities.
  2. Costs for the proposed research in HIV/AIDS-malignancy cannot have been included in the original award.
  3. The Principal Investigator (PI) for the supplement must be the PI of the parent award.

The purpose of the administrative supplement is to provide support for a partnership that will engage the community in conducting outreach and preliminary research activities at the intersection of cancer and HIV/AIDS. This will require a needs assessment as a basis for future activities, such as culturally sensitive and appropriate HIV/AIDS awareness and education or other interventions (e.g., navigation to screening and treatment services). These activities should facilitate increased prevention, early detection, and support for individuals diagnosed as HIV+ who are at risk for an HIV-associated/AIDS-related cancer. HIV-associated and AIDS-related cancers include certain cancer types that are more likely to occur in people who are infected with the human immunodeficiency virus, such as non-Hodgkin lymphoma, Hodgkin lymphoma and cancers of the lung, mouth, cervix, and digestive system, []. In some communities, the partnership may choose to focus on prevention, early detection or treatment of common cancers, such as breast or prostate cancer, as they present in HIV+ persons from racial/ethnic minority and underserved populations. Such applications will also be responsive to this opportunity.

Another purpose of the supplement is to identify and train a cadre of new and emerging researchers in one of the major co-morbidities of HIV infection – cancer – a problem increasingly found in minority and underserved populations. It is expected that research training will include use of Community Based Participatory Research (CBPR).

CBPR is a research approach that mandates a partnership between academically trained experts and members of a community, with all parties interested in addressing a common research problem. This approach requires for the community to be a full research partner, participating in the planning, development, implementation, evaluation and dissemination of the research. (See e.g. Israel, Schulz AJ, Becker AB et al, 2003; Israel, Eng, Schulz and Parker, 2005 for further detail on the CBPR approach).

Brief Overview of the Project/Program:

The focus of the supplement will be on racial/ethnic minority and underserved populations in the U.S. who are HIV+, or at high risk of HIV infection. HIV+ persons are at particular risk of a number of cancers associated with HPV (e.g., oral, cervical, anal cancer), lymphoma, and other malignancies. In addition, more information is needed on prevention and treatment of other common cancers, such as lung, breast or prostate in HIV+ individuals, especially among members of racial/ethnic minorities. This initiative will engage communities to address the co-occurrence of HIV and cancer in their communities. This partnership will serve to ensure a community focus in the prevention, early detection or treatment of HIV-related malignancies among domestic populations at particular risk of both HIV/AIDS and cancer-related health disparities (i.e., racial/ethnic minorities and other underserved populations) through community engagement. These partnerships will form the basis for future activities using Community-Based Participatory Research (CBPR), through which academically trained scientists and community members work collaboratively on all phases of research.

CRCHD programs (CNP, MI/CCP, PNRP) are eligible to apply. The Community Networks Program (CNP) uses CBPR to increase awareness on how to access and use primary prevention services and early detection procedures, provide culturally tailored education on cancer treatment, and identify other cancer-related needs. In addition, the CNP aims to train a cadre of new and emerging investigators in conducting cancer health disparities research using CBPR. The Minority Serving Institution/Cancer Center Program (MI/CCP) is composed of a Minority Serving Institution and a NCI Cancer Center and supports the development of effective research, education, and outreach programs to encourage diversity among competitive researchers and to reduce cancer health disparities. The Patient Navigation Research Program (PNRP) utilizes patient navigation (a form of intensive case management) to increase access to early detection services and care, and as a bridge between the community and the health care system.

The applicant is highly encouraged to collaborate with an NIH supported HIV/AIDS research program such as a Center for AIDS Research (CFAR) or an AIDS Malignancy Consortium (AMC) site. While not required upon application, the Principal Investigator should demonstrate an ability to build this type of collaboration and address plans for doing so in the future.

  • The CFAR ( program emphasizes the importance of interdisciplinary collaboration, especially between basic and clinical investigators, and includes translational research in which findings from the laboratory are brought to the clinic. There is also an emphasis on inclusion of minority group members and of HIV prevention and behavioral change research. There are 20 CFARs located at academic and research institutions throughout the U.S.
  • The AMC ( is comprised of 24 sites in the U.S. that test protocols for the treatment and seek further understanding of the dynamics of HPV-related cancers, lymphomas and other malignancies.

Other sources of information include HIV-related longitudinal studies that have a strong history of recruiting members of minority communities. The Multicenter AIDS Cohort Study (MACS) is an ongoing prospective study of the natural and treated histories of HIV-1 infection in homosexual and bisexual men conducted in 4 urban settings ( The Women’s Interagency HIV Study (WIHS) investigates the impact of HIV infection among women in the US (

All applications must closely engage the community through collaboration between academically trained scientists and members of a community, with all parties interested in identifying a common research problem. CNPs are likely to fully develop CBPR programs during the supplement period, while MI/CCPs may focus on community outreach and investigator training, and PNRPs may focus on preparing for navigation of HIV+ patients in the cancer screening and/or treatment system. In all situations the CRCHD program must ensure that community members, through an identified agency, organization, consortium or other recognized group, has a strong voice in the design, implementation, evaluation and dissemination of results of the supplemental study, and can be developed into an equal partner for future funding opportunities. All partners must work collaboratively to meet the needs of those at risk of, or affected by, HIV-related malignancies. During the one year timeline, it is expected that the supplements will lead to:

  • Identification of a viable and committed community partner.
  • Education of community members in principles of research, and of the interaction between cancer and HIV infection (emphasis may be on prevention, early detection, and/or treatment).
  • Implementation of a structure for community members to advise the CRCHD grantee and any current or future AIDS-malignancy collaboration.
  • Community needs assessment to identify the focus of the partnership.

The longer-term purpose of the supplement is to stimulate partnerships to develop a plan for future CBPR studies based upon the needs it identifies during this supplemental period. Such needs or research could include (this list is not exhaustive):

  • Increase participation in AMC clinical trials
  • Train providers in colposcopy, or other diagnostic interventions, while working with HIV+ individuals in collaboration with community members to utilize these services.
  • Epidemiological and biospecimen studies related to HPV-related cancers.
  • Outreach and education regarding HPV vaccination and different modes of testing.
  • Comparison of the impact of common cancers among HIV+ and non-infected minority populations (e.g., prostate, lung).
  • Train patient navigators to navigate patients with one or more HIV-related malignancy.
  • Train new and emerging cancer health disparities researchers.
  • Evidence-based research on comorbidities found in HIV+ patients with cancer (e.g., depression, metabolic disorders) as a basis for future interventions.

Ultimately, collaborations among CRCHD programs, NIH-funded AIDS programs, and communities will allow for cross-training of investigators from different disciplines – and at different levels of scientific expertise – but all with the common goal of generating research findings in the area of HIV-related malignancies among minorities and underserved population groups. Examples include the training of cancer health disparities researchers in HIV/AIDS behavioral research; development of basic science curricula for community researchers; training patient navigators in motivational or empowerment principles to ensure adherence to protocol treatment; or, mentoring students to work with community members to understand the advantages of biospecimen study participation.

For the supplement, the applicant will need to propose activities that consider the current level of community involvement. At minimum, all applications should address 1) use of community engagement, 2) feasibility of sustaining this partnership in the future for larger evidence-based studies and interdisciplinary research and research training, and 3) current or future plans for partnering of the CRCHD program with an NIH-funded AIDS program (e.g., CFAR or AMC).

Application and Submission Guidelines

Applicants are encouraged to discuss their administrative supplement request with the CRCHD Program Director prior to submission.

Use the PHS 398 research grant application instructions and forms (rev. 11/07) at Follow standard PHS 398 instructions for font size. NIH will return applications that are not submitted on the 9/04 version. For further assistance contact GrantsInfo at 301/435-0714 or via email at

All requests must include the following:

  • Cover letter: Request the administrative supplement and refer to and provide contact information for the project leader of the application. The cover letter must be signed by the application’s Principal Investigator and the appropriate business official of the institution. Include the following statement: “Per supplement instructions, a detailed budget request is enclosed.”
  • PHS 398 Face page (PHS 398, Form Page 1):
    • Item 1: The request must have the same title as the original award. Please include the number of the original grant.
    • Item 2: Identify the supplement as “Research on HIV/AIDS-related Cancers Among Racial/Ethnic Minority and Underserved Persons in the U.S.”
    • Item 3: The request must have the same PI as the original grant.
    • Item 4: Request a one year period of support. There must be an active original award during the entire funding period.
    • Items 7A-8b: Denote the direct and total costs for the year. Total costs should not exceed those stated under the CRCHD General Guidelines above.
  • PHS Biographical Sketch Format Page: For key personnel in program (MI/CCP, PNRP or CNP) that will be involved with the supplement.
  • PHS Other Support Format Page: Documentation of active research funding (i.e., NIH, other federal, private sources).
  • Detailed Budget for Initial Budget Period: [PHS 398 (O9/2004), Form pages 4-6).] Supplements are for 1-year, $200,000 in total costs. The supplement application should be submitted by the CRCHD program and include all costs associated with developing the AIDS partnership and community collaboration. All applicants must provide an itemized budget, signed by the grantee institution’s business office.


  • Describe the roles of the proposed partnerships, and staff members from each partner.
  • Give the qualifications for proposed applicants or candidates.
  • Indicate the specific activities that will be undertaken as part of the supplement. The activities must utilize CBPR principles
  • Describe how each activity will meet the goal of initiating a research program to ensure that members of racial/ethnic minorities and other underserved population groups receive HIV-related cancer prevention, early detection and/or treatment services.

Provide a listing of current and relevant publications, specific to the research area.

Post Award Requirements
Final Report. Within 90 days after the conclusion of the funded activity, the applicant must submit to their respective grant and CRCHD Program Official, a Final Progress Report or a section in the parent grant’s Final Progress Report.

Submission of Administrative Supplement Request
Ms. LaShell Gaskins
6116 Executive Boulevard
Suite 602; MSC 8341
Rockville, MD 20852

Contact Information:
Please contact the Program Director assigned to the parent grant for questions related to scientific or programmatic content and to determine if the supplement fits within the approved scope of the project.

Please contact the Grants Management Specialist assigned to the parent grant for questions related to administrative or budgetary requirements specific to a supplement to the grant. This is a one-time announcement and formal requests must be received on or before July 20, 2009. Late applications will not be accepted. Note the NIH Center for Scientific Review (CSR) IS NOT involved in receipt and processing of these requests. Applicants are strongly encouraged to submit their administrative supplement requests electronically as an e-mail attachment in PDF format; however, the scanned application must include the signature of an official from the institution’s business office.

All proposals will undergo review for scientific and technical merit by a committee of NCI staff with expertise in the disciplines pertaining to cancer health disparities. Those proposals judged to be responsive to the intent of this initiative will be evaluated based on the review criteria below, and prioritized accordingly.


  • Relevance of the proposed activities to the parent grant and determination that the proposed activities will lead to a viable HIV-related partnership.
  • Adequate progress of the parent grant appropriate to the current stage of the project.
  • Appropriate and well-described plan to accomplish the goals within the timeframe proposed.
  • Expertise of the research/scientific team proposed to conduct and achieve the goals of the supplemental study or accelerate the tempo of scientific research in engaging the community in HIV-related cancer research among racial/ethnic minorities and underserved populations.
  • Relevance to target areas/priorities.
Awards will be based on the following criteria: a) scientific and technical merit of proposed project; and b) availability of funds.

The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourages the use of all tobacco products. In addition, Public Law 103-227, the Pro- Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.

Program Contacts:
The primary program contact is:

Martha L. Hare, Ph.D., RN
Program Director
Center to Reduce Cancer Health Disparities, NCI
Phone: 301-594-1908

The applicant may also contact the Program Director for the parent program:

CNP: Leslie Cooper, Ph.D., RN
Program Director
Center to Reduce Cancer Health Disparities, NCI
Phone: 301-402-5557

MI/CCP: Carmen P. Moten, Ph.D., M.P.H.
Program Director
Center to Reduce Cancer Health Disparities, NCI
Phone: 301-496-8589

PNRP: Martha L. Hare, Ph.D., RN
Program Director
Center to Reduce Cancer Health Disparities, NCI
Phone: 301-594-1908

Updated: 07/23/09